ProtoCentral HealthyPi 4

ESP32 health monitor board with ECG, PPG, and respiration sensors - great for wearable biomedical projects.

Micro-USB
ProtoCentral HealthyPi 4 board
65 × 56 mm
ESP32
MCU
240MHz
clock
4MB
flash
520KB
SRAM
25· 16 ADC
GPIO
BLE 4.2+ WiFi
radio
On this page

ProtoCentral HealthyPi 4 Pinout

25 pins · 2.54 mm pitch
PinGPIOLabelsStatusCapabilitiesNotes
10A11T1strappingadc · touch
21TXPWMuartuart
32SSA12T2PWMstrappingadc · touch · spi
43RXPWMuartuart
54A10T0AFE4490_PWDN_PINPWMsafeadc · touch
612A15T5PWMstrappingadc · touch
713A14T4ADS1292_CS_PINPWMstrappingadc · touch
814A16T6ADS1292_START_PINPWMstrappingadc · touch
915LED_BUILTINA13T3PWMstrappingadc · touch
1016SLIDE_SWITCHPWMsafe-
1117KEY_BUILTINPUSH_BUTTONPWMsafe-
1218SCKPWMsafespi
1319MISOPWMsafespi
1421SDAAFE4490_CS_PINPWMsafei2c
1522SCLPWMsafei2c
1623MOSIPWMsafespi
1725A18DAC1PWMsafeadc · dac
1826A19DAC2ADS1292_DRDY_PINPWMsafeadc · dac
1927A17T7ADS1292_PWDN_PINPWMsafeadc · touch
2032A4T9PWMsafeadc · touch
2133A5T8PWMsafeadc · touch
2234A6strappingadc
2335A7strappingadc
2436A0strappingadc
2539A3AFE4490_DRDY_PINstrappingadc
25 GPIOs broken out 13 free · 12 need care · 0 to avoid

Start with these

13 pins with no boot or system involvement
A10GPIO4SLIDE_SWITCHGPIO16KEY_BUILTINGPIO17SCKGPIO18MISOGPIO19SDAGPIO21SCLGPIO22MOSIGPIO23A18GPIO25A19GPIO26A17GPIO27A4GPIO32A5GPIO33

Freely assignable - no strapping, flash, USB or JTAG duties. Ideal first picks for buttons, sensors and LEDs.

Fine - with a little care

12 pins · 11 things to know
A11GPIO0 Bootstrapping pin (enter bootloader when low); internal pull-up. Strapping

Must be HIGH during boot for normal startup; if held LOW on reset, forces flash programming mode.

TXGPIO1 Default UART0 TX pin for USB-serial programming and console. UART

Connected to on-board USB-UART for uploading and logs; drives serial output at boot, so using as GPIO can disrupt programming or console.

SSGPIO2 Bootstrapping pin (must be low or floating at reset); internal pull-down. Strapping

If driven HIGH on reset (while IO0 is LOW), selects an unsupported SDIO boot mode, causing boot failure.

RXGPIO3 Default UART0 RX pin for USB-serial programming (console input). UART

Used for receiving data from USB-UART (programming); also pulled HIGH at boot for console communication, so using as GPIO can disrupt uploads.

A15GPIO12 Bootstrapping pin; JTAG TDI; sets flash voltage (VDD_SDIO); also HSPIQ (flash data line). Strapping

Keep LOW during boot (internal PD); pulling HIGH at reset selects 1.8V flash mode, causing flash brownout if 3.3V flash is used.

A14GPIO13 JTAG clock pin (TCK); also ADC2 channel 4 / Touch4 input. JTAG

Used for JTAG debugging (TCK); avoid using as GPIO if JTAG is needed.

A16GPIO14 JTAG mode select pin (TMS); also HSPI CLK and PWM-capable GPIO. JTAG

Used for JTAG debugging (TMS); driving it as GPIO may interfere with JTAG or produce spurious signals at boot.

LED_BUILTINGPIO15 Bootstrapping pin; JTAG TDO; controls UART0 boot log output; also HSPICS0 (secondary SPI CS). Strapping

Keep HIGH during boot (internal PU); if LOW on reset, bootloader log is silenced and boot mode may change.

A6GPIO34 Input-only GPIO (no output driver); ADC1 channel 6. Other

Cannot be used as output (no drive capability); only suitable for analog/digital input.

A7GPIO35A3GPIO39 Input-only GPIOs with ADC1 channels - no output driver Other

Cannot be used as output; only suitable for input.

  • A7Input-only GPIO (no output driver); ADC1 channel 7.
  • A3Input-only GPIO (no output); ADC1 channel 3, Hall sensor VN.
A0GPIO36 Input-only GPIO (no output); ADC1 channel 0, Hall sensor VP. Other

Cannot be used as output; only suitable for input (e.g., analog read).

These are recommendations, not hard rules - with the right pull-ups, timing and boot-state awareness most pins can be made to work. When in doubt, start green.

The ProtoCentral HealthyPi 4 pinout brings out 25 GPIO pins at a 2.54 mm pitch - every one of them usable in your project.

For peripherals, I²C is mapped to SDA on GPIO21 and SCL on GPIO22; the SPI bus (MOSI, MISO, SCK, SS) is broken out in full; TX/RX on GPIO1 and GPIO3 cover serial logging and flashing.

On the analog side there are 16 ADC-capable pins for sensors and battery monitoring, 10 capacitive-touch inputs and 2 true DAC outputs.

If you want zero surprises, A10, SLIDE_SWITCH, KEY_BUILTIN, SCK and 9 more are free of any such role - the safest first picks. 12 of the exposed pins carry boot-time or system duties on the ESP32 (A11, TX, SS and 9 more).

Getting started

flash your first firmware in ~2 minutes
Tool:
1
Connect over USB
Install your USB-serial driver (CH340 / CP210x) if no port appears. Not detected? Hold BOOT while plugging in.
2
Match & flash
Set the Tools options shown, then click Upload.
3
Verify it runs
GPIO4 toggles - wire an LED and resistor to it, or change the pin to your board's own LED.
Set these in Tools · leave everything else at default
Arduino IDE 2.x - Tools Copy
Board: "ESP32 Dev Module"▸
Flash Size: "4MB (32Mb)"▸
Flash Mode: "DIO"▸
Partition Scheme: "Default 4MB with spiffs (1.2MB APP/1.5MB SPIFFS)" (default)▸
Upload Speed: "921600"▸
▸ every other Tools option - leave at default
Board: ESP32 Dev Module
Flash Size: 4MB (32Mb)
Flash Mode: DIO
Partition Scheme: Default 4MB with spiffs (1.2MB APP/1.5MB SPIFFS)
Upload Speed: 921600
Find it: Tools ▸ Board ▸ ESP32 Arduino ▸ ESP32 Dev Module
blink.ino Copy
// toggle GPIO4 - wire an LED and resistor to it
void setup() {
  pinMode(4, OUTPUT);
}
void loop() {
  digitalWrite(4, HIGH); delay(500);
  digitalWrite(4, LOW);  delay(500);
}
board to selectesp32dev⧉ copy
platformio.ini Copy
[env:healthypi4]
platform = espressif32
board = esp32dev
framework = arduino
monitor_speed = 115200
upload_speed = 921600
Find it: PlatformIO Home ▸ Boards, search esp32dev - or type it after board =.
board to selectesp32dev⧉ copy
device.yaml Copy
esp32:
  board: esp32dev
  variant: esp32
  framework:
    type: esp-idf

# blink - GPIO4
output:
  - platform: gpio
    pin: 4
    id: led_out
light:
  - platform: binary
    name: "LED"
    output: led_out
Find it: search ESPHome's board list for esp32dev (same ids as PlatformIO).
esptool doesn't pick board settings - a prebuilt .bin already has them baked in. This is just the raw flash command.
terminal Copy
esptool.py --chip esp32 --port /dev/ttyACM0 \
  --baud 921600 write_flash 0x1000 firmware.bin
--port = your /dev/tty* (macOS/Linux) or COMx (Windows).
Build details: sketch space 1310720 B · data 327680 B · DIO

Specifications

ESP32 · 65 × 56 mm · vs other ESP32 chips →
Compute
MCU
ESP32
Clock
240 MHz
SRAM · Flash
520 KB · 4MB
Radio
Wi-Fi
802.11 b/g/n
Bluetooth
4.2 LE
Antenna
PCB
I/O
GPIO · ADC
25 · 16
UART · I²C · SPI
3 · 2 · 2
PWM
16 channels
Power
USB
Micro-USB
Serial
-
Boot address
0x1000
Electrical
Input
5V USB · 3.7V LiPo
Consumption
-
Regulator
-
Flashing
Upload · OTA
esptool_py · esp_ota
Flash · Boot mode
DIO · DIO
Sketch · Data
1.25 MB · 320 KB

Dimensions

56 mm65 mm
65 × 56 mm · pin pitch 2.54 mm
The ProtoCentral HealthyPi 4 uses esptool_py for firmware uploads, esp_ota for over-the-air (OTA) updates. Flash mode is DIO with DIO boot mode. The maximum sketch size is 1.25 MB with 320 KB available for data.

About this board

At its core is the ESP32 - a dual-core Xtensa with both Bluetooth Classic and BLE.

Expect to pay about $199.00 - above the ~$20 typical for ESP32 boards.

Onboard you'll find a Qwiic connector and battery charging via JST-PH 2.0.

  • ECG & respiration: TI ADS1292R 24-bit analog front-end (107 dB SNR)
  • Pulse oximetry (PPG/SpO2): TI AFE4400 front-end with integrated LED driver and 22-bit ADC
  • Skin temperature: Maxim MAX30208 digital body-temperature sensor
  • Raspberry Pi HAT form factor with 40-pin GPIO header
  • 1000 mAh LiPo battery with onboard charging and power management
  • Slide switch toggles between HAT (continuous) and standalone wearable mode
  • DB9 connector for ECG electrode cable and 3.5 mm jack for the SpO2 finger sensor
  • 2x SparkFun Qwiic I2C connectors for sensor expansion
  • Fully open-source hardware and firmware (Arduino IDE and ESP-IDF)

Where to buy

prices are typical street prices
ProtoCentral HealthyPi 4
ProtoCentral HealthyPi 4
$199.00per unit, typical

Resources

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